Phil Pescoe, the 37-year-old emergency physician at Deaconess Hospital in San Francisco, becomes alarmed by a dramatic increase in the number of deaths on the East Annex (the Alzheimer's Ward). The deaths coincide with the initiation of a new drug study on the annex where a team of neurologists have been administering "NAF"—an experimental and highly promising treatment for Alzheimer's disease—to half of the patients on the ward.

Mysteriously, the hospital pushes forward with the study even though six patients have died since the start of the trial. Pescoe teams up with Clara Wong—a brilliant internist with a troubled past—to investigate the situation. Their inquiries lead them unwittingly into the cutthroat world of big-business pharmaceuticals, where they are threatened to be swept up and lost before they have the opportunity to discover the truth behind the elaborate cover-up.

With the death count mounting, Pescoe and Wong race against time to save the patients on the ward and to stop the drug manufacturer from unleashing a dangerous new drug on the general populace.